منابع مشابه
MIRD Pamphlet No. 22 (abridged): radiobiology and dosimetry of alpha-particle emitters for targeted radionuclide therapy.
The potential of alpha-particle emitters to treat cancer has been recognized since the early 1900s. Advances in the targeted delivery of radionuclides and radionuclide conjugation chemistry, and the increased availability of alpha-emitters appropriate for clinical use, have recently led to patient trials of radiopharmaceuticals labeled with alpha-particle emitters. Although alpha-emitters have ...
متن کاملFunctionalized TiO2 nanoparticles labelled with 225Ac for targeted alpha radionuclide therapy
The 225Ac radioisotope exhibits very attractive nuclear properties for application in radionuclide therapy. Unfortunately, the major challenge for radioconjugates labelled with 225Ac is that traditional chelating moieties are unable to sequester the radioactive daughters in the bioconjugate which is critical to minimize toxicity to healthy, non-targeted tissues. In the present work, we propose ...
متن کاملA Critical Review of Alpha Radionuclide Therapy—How to Deal with Recoiling Daughters?
This review presents an overview of the successes and challenges currently faced in alpha radionuclide therapy. Alpha particles have an advantage in killing tumour cells as compared to beta or gamma radiation due to their short penetration depth and high linear energy transfer (LET). Touching briefly on the clinical successes of radionuclides emitting only one alpha particle, the main focus of ...
متن کاملA Physical Model of Lyman Alpha Emitters
We present a simple physical model for populating dark matter (DM) halos with Lyman Alpha Emiiters (LAEs) and predict the physical properties of LAEs at z ≈ 3− 7. The central tenet of this model is that the Lyα luminosity is proportional to the star formation rate (SFR) which is directly related to the halo mass accretion rate. The only free parameter in our model is then the starformation effi...
متن کاملRadium–the Benchmark for Alpha Emitters
States have handled plutonium. Of those workers, only about fifty, all from the nuclear-weapons complex, have been exposed to plutonium at levels above the maximum permissible dose. Because so few people have high-dose exposures, we have little direct information about the risk of plutonium in man. This leads to the ironic situation that the better we protect our workers, the less we know about...
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ژورنال
عنوان ژورنال: Radiation Diagnostics, Radiation Therapy
سال: 2019
ISSN: 2707-0700,2707-0697
DOI: 10.37336/2707-0700-2019-4-4